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PPP2R1A Human shRNA Plasmid Kit (Locus ID 5518)

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SKU
TR310227
PPP2R1A - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 5518
Synonyms MRD36; PP2A-Aalpha; PP2AA; PP2AAALPHA; PR65A
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PPP2R1A - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5518). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC001537, NM_014225, NR_033500, NM_014225.1, NM_014225.2, NM_014225.3, NM_014225.4, NM_014225.5, BC001537.2, BC026733, NM_001363656, NM_014225.6
UniProt ID P30153
Summary This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. provided by RefSeq, Apr 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors
Toda-Ishii, Akaike, Suehara et al
Mod. Pathol. (2016)
Cited by 22
AI Summary: OriGene’s human PPP2R1A plasmid was used to generate constructs for retroviral transduction in GIST cell lines, enabling the study of PPP2R1A mutation effects on cell proliferation and kinase phosphorylation.
Snippet: Preparation of Retrovirus and Transduction of Cell Lines. For retrovirus production, the pCX4 27 and pGEM (Promega) vector systems were used. A plasmid encoding human PPP2R1A (Origene) was used to generate constructs, which were subcloned into pGEM. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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