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PRB1 Human shRNA Plasmid Kit (Locus ID 5542)

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SKU
TR310199
PRB1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 5542
Synonyms PM; PMF; PMS; PRB1L; PRB1M
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PRB1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5542). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_005039, NM_199353, NM_199354, NM_199353.1, NM_199353.2, NM_005039.1, NM_005039.2, NM_005039.3, NM_199354.1, NM_199354.2, BC044827, BC141917, NR_160307
UniProt ID P04280
Summary This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Medium" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. provided by RefSeq, Nov 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Transcriptional activation by pRB and its coordination with SWI/SNF recruitment
Flowers, Beck, Moran
Cancer Res (2010) 70 (21), 8282-7 DOI: 10.1158/0008-5472.CAN-10-2205
AI Summary: In this study, OriGene’s pRB expression plasmid (RC200307) and pRB shRNA (TF313079) were used to manipulate pRB levels in cells, enabling the authors to investigate pRB’s direct role in activating the alkaline phosphatase promoter and coordinating SWI/SNF recruitment during osteoblast differentiation.
FigureFigure
Showing 1-1 of 1 papers.
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