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EP4 (PTGER4) Human shRNA Plasmid Kit (Locus ID 5734)

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SKU
TR310079
PTGER4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Other products for "EP4 or NM_000958"

Specifications
Specifications
Product Data
Locus ID 5734
Synonyms EP4; EP4R
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PTGER4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5734). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000958, NM_000958.1, NM_000958.2, BC101534, BC101534.1, BC027934, BC113523, BM312677, NM_000958.3
UniProt ID P35408
Summary The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties
Kundu, Ma, Kochel et al
Breast Cancer Res. Treat. (2013)
Cited by 63
AI Summary: In this study, OriGene's EP4 shRNA was used to silence the EP4 gene in breast cancer cells, enabling the researchers to investigate the role of EP4 in supporting cancer stem cell properties and tumor initiation.
Snippet: For some studies, the targeting vector was from OpenBiosystems, Huntsville, AL [21];for other studies an EP4shRNA was obtained from OriGene, Rock- ville, MD. MDA-MB-231-luc cells were a generous gift of Dr. Stuart Martin, UMB. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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