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PTPD1 (PTPN21) Human shRNA Plasmid Kit (Locus ID 11099)

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SKU
TR310062
PTPN21 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Other products for "PTPD1 or NM_007039"

Specifications
Specifications
Product Data
Locus ID 11099
Synonyms PTPD1; PTPRL10
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PTPN21 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 11099). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_007039, NM_007039.1, NM_007039.3, BC143846, BC143847, BC167856, BM930068, NM_007039.4
UniProt ID Q16825
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

BMX negatively regulates BAK function thereby increasing apoptotic resistance to chemotherapeutic drugs
Fox, Storey
Cancer Res. (2015)
AI Summary: OriGene’s pRS shRNA construct was used as a control in experiments assessing the effects of BMX and PTPN21 gene silencing on apoptotic resistance in cancer cells.
Snippet: Cells positive for shRNA constructs against BMX, PTPN21 and a control shRNA construct (pRS;Origene) were selected with 0.4 μg/ml puromycin. Immunoprecipitation Protein A/G agarose beads (Santa Cruz) and 1µg antibody ... Cite SaveSaving
Showing 1-1 of 1 papers.
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