SAP1 (PTPRH) Human shRNA Plasmid Kit (Locus ID 5794)

SKU
TR310053
PTPRH - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*
Specifications
Specifications
Product Data
Locus ID 5794
Synonyms R-PTP-H; SAP1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PTPRH - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5794). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001161440, NM_002842, NM_002842.1, NM_002842.2, NM_002842.3, NM_002842.4, NM_001161440.1, NM_001161440.2, BC111715, BC111716, NM_002842.5, NM_001161440.3
UniProt ID Q9HD43
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jun 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Tyrosine dephosphorylation is required for Bak activation in apoptosis
Fox, Ismail, Azad et al
EMBO J (2010) 29 (22), 3853-68 DOI: 10.1038/emboj.2010.244
Cited by 47
AI Summary: OriGene products contributed to this study by providing the PTPN5 siRNA (OriGene, catalog number SR303330) used for gene silencing experiments and the PTPN5 overexpression plasmid (OriGene, catalog number RC204307) used to modulate protein expression, enabling the authors to investigate the role of PTPN5 in Bak dephosphorylation and apoptosis.
Showing 1-1 of 1 papers.
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