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RGS4 Human shRNA Plasmid Kit (Locus ID 5999)

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SKU
TR309833
RGS4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Other products for "RGS4 or NM_001102445"

Specifications
Specifications
Product Data
Locus ID 5999
Synonyms RGP4; SCZD9
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components RGS4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5999). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001102445, NM_001113380, NM_001113381, NM_005613, NM_005613.2, NM_005613.3, NM_005613.4, NM_005613.5, NM_001102445.1, NM_001102445.2, NM_001113381.1, NM_001113380.1, BC051869, BC051869.1, BC000737, NM_005613.6
UniProt ID P49798
Summary Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4
Xie, Wolff, Wei et al
Cancer Res (2009) 69 (14), 5743-51 DOI: 10.1158/0008-5472.CAN-08-3564
AI Summary: OriGene products contributed to this study by providing the RGS4 shRNA (OriGene, TF311666) used to specifically knock down RGS4 expression, enabling the authors to demonstrate the role of RGS4 in inhibiting breast cancer cell migration and invasion.
FigureFigure
Showing 1-1 of 1 papers.
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