CD162 (SELPLG) Human shRNA Plasmid Kit (Locus ID 6404)
Specifications
| Product Data | |
| Locus ID | 6404 |
|---|---|
| Synonyms | CD162; CLA; PSGL-1; PSGL1 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | SELPLG - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 6404). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001206609, NM_003006, NM_003006.1, NM_003006.2, NM_003006.3, NM_003006.4, NM_001206609.1, BC029782, BC029782.1, NM_001206609.2 |
| UniProt ID | Q14242 |
| Summary | This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.provided by RefSeq, Apr 2011 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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