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SMAD2 Human shRNA Plasmid Kit (Locus ID 4087)

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SKU
TR309255
SMAD2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 4087
Synonyms hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components SMAD2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 4087). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001003652, NM_001135937, NM_005901, NM_005901.1, NM_005901.2, NM_005901.3, NM_005901.4, NM_005901.5, NM_001003652.1, NM_001003652.2, NM_001003652.3, NM_001135937.1, NM_001135937.2, BC014840, BC014840.1, BC025699, BC025699.1, NM_001003652.4, NM_005901.6
UniProt ID Q15796
Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. provided by RefSeq, May 2012
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells
Guo, Jose, Chen
Am. J. Physiol., Cell Physiol. (2011) 300 (6), C1415-21 DOI: 10.1152/ajpcell.00204.2010
Cited by 35
AI Summary: OriGene products contributed to this study by providing Smad2 and Smad3 shRNA, which were used to efficiently knock down endogenous Smad2 and Smad3 expression and investigate their roles in RGC-32-mediated epithelial-mesenchymal transition in human renal tubular cells.
Snippet: RGC-32, Smad2, and Smad3 short hairpin interfering RNAs (shRNA) were purchased from Origene (Rockville, MD). ... G: Smad2 (shS2) and Smad3 shRNA (shS3) efficiently knock down endogenous Smad2 and Smad3 expression, respectively.
Showing 1-1 of 1 papers.
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