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SOX2 Human shRNA Plasmid Kit (Locus ID 6657)

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SKU
TR309173
SOX2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Other products for "SOX2 or NM_003106"

Specifications
Specifications
Product Data
Locus ID 6657
Synonyms ANOP3; MCOPS3
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components SOX2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 6657). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq BC013923, NM_003106, NM_003106.1, NM_003106.2, NM_003106.3, BC013923.2, BM668019, BM722297, NM_003106.4
UniProt ID P48431
Summary This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Hypoxia regulates SOX2 expression to promote prostate cancer cell invasion and sphere formation
Bae, Dai, Vieweg et al
Am J Cancer Res (2016) 6 (5), 1078-88
AI Summary: OriGene products, specifically the SOX2 shRNA (Cat# TG312386) and HIF-1α and HIF-2α shRNAs (Cat# TG310881 and TG313411), were used in this study to genetically knock down these genes in prostate cancer cell lines, enabling the authors to investigate their roles in hypoxia-induced invasion and sphere formation.
SOX2 expression in the developing, adult, as well as, diseased prostate
Yu, Cates, Morrissey et al
Prostate Cancer Prostatic Dis. (2014)
Cited by 59
AI Summary: OriGene contributed to this study by providing the shSOX2 constructs used to validate the specificity of the SOX2 antibody via western blotting.
Snippet: Validation of SOX2 antibody. The specificity of SOX2 antibody was validated by western blotting using cell lysate collected from control PC3 cells and PC3/shSOX2 cells (Figure 1). The shSOX2 constructs were purchased from Origene (Rockville, MD, USA). ... Cite SaveSaving
Showing 1-2 of 2 papers.
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