TDP1 Human shRNA Plasmid Kit (Locus ID 55775)
SKU
TR308891
TDP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 55775 |
|---|---|
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | TDP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 55775). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001008744, NM_001330205, NM_018319, NM_001008744.1, NM_018319.1, NM_018319.2, BC015474, BC015474.1, BC006083, BC107877, BM661793, NM_018319.4, NM_001008744.2 |
| UniProt ID | Q9NUW8 |
| Summary | The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). provided by RefSeq, Aug 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies
Igaz, Kwong, Chen-Plotkin et al
J Biol Chem (2009) 284 (13), 8516-24 DOI: 10.1074/jbc.M809462200
Igaz, Kwong, Chen-Plotkin et al
J Biol Chem (2009) 284 (13), 8516-24 DOI: 10.1074/jbc.M809462200
AI Summary: In this study, OriGene’s TDP-43 expression plasmids (e.g., pCMV6-TDP-43) were used to express TDP-43 C-terminal fragments in cultured cells, enabling the authors to model and analyze pathological features of TDP-43 proteinopathies such as cytoplasmic aggregation, ubiquitination, and abnormal phosphorylation.
Showing 1-1 of 1 papers.
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