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TFEB Human shRNA Plasmid Kit (Locus ID 7942)

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SKU
TR308867
TFEB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Other products for "TFEB or NM_001167827"

Specifications
Specifications
Product Data
Locus ID 7942
Synonyms ALPHATFEB; BHLHE35; TCFEB
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components TFEB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 7942). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001167827, NM_001271943, NM_001271944, NM_001271945, NM_007162, NM_007162.1, NM_007162.2, NM_001167827.1, NM_001167827.2, NM_001271943.1, NM_001271944.1, NM_001271945.1, BC032448, BC032448.1, NM_001271944.2, BC006225, NM_001167827.3
UniProt ID P19484
Summary Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Curcumin Analogue C1 Promotes Hex and Gal Recruitment to the Plasma Membrane via mTORC1-Independent TFEB Activation
Magini, Polchi, Di Meo et al
Int J Mol Sci (2019) 20 (6) DOI: 10.3390/ijms20061363
AI Summary: OriGene contributed shRNA expression constructs for TFEB RNA interference and a scrambled shRNA control, which were used to assess the role of TFEB in lysosomal glycohydrolase expression and recruitment in the study.
Snippet: … TFEB RNA Interference. TFEB RNAi was performed by using shRNA expression constructs which were purchased from Origene (Rockville, MD, USA). … TFEB RNA Interference. TFEB RNAi was performed by using shRNA expression constructs which were purchased from Origene (Rockville, MD, USA). …
Oncogenic H-Ras Up-Regulates Acid β-Hexosaminidase by a Mechanism Dependent on the Autophagy Regulator TFEB
Urbanelli, Magini, Ercolani et al
PLOS ONE (2014) 9, e89485
AI Summary: OriGene contributed shRNA expression constructs targeting TFEB and a scrambled shRNA control, which were used to investigate the role of TFEB in the study.
Snippet: Full-length human TFEB was cloned into KpnI/EcoRI sites of pcDNA6 as previously described [21]. shRNA expression constructs targeting TFEB were purchased from Origene (Rockville, USA). Scrambled shRNA (Origene) was used as control. ... Cite SaveSaving
Showing 1-2 of 2 papers.
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