TFEB Human shRNA Plasmid Kit (Locus ID 7942)

SKU TR308867

TFEB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 7942
• Synonyms: ALPHATFEB; BHLHE35; TCFEB
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: TFEB - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 7942). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001167827, NM_001271943, NM_001271944, NM_001271945, NM_007162, NM_007162.1, NM_007162.2, NM_001167827.1, NM_001167827.2, NM_001271943.1, NM_001271944.1, NM_001271945.1, BC032448, BC032448.1, NM_001271944.2, BC006225, NM_001167827.3
• UniProt ID: P19484
• Summary: Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937).[UniProtKB/Swiss-Prot Function]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient