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TIMP1 Human shRNA Plasmid Kit (Locus ID 7076)

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SKU
TR308814
TIMP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 7076
Synonyms CLGI; EPA; EPO; HCI; TIMP; TIMP-1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components TIMP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 7076). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_003254, NM_003254.1, NM_003254.2, BC000866, BC000866.1, BC007097
UniProt ID P01033
Summary This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Regulation of soluble vascular endothelial growth factor receptor 1 secretion from human endothelial cells by tissue inhibitor of metalloproteinase 1
Bruegmann, Gruemmer, Neulen et al
Mol Hum Reprod (2009) 15 (11), 749-56 DOI: 10.1093/molehr/gap053
Cited by 8
AI Summary: In this study, OriGene's TIMP-1 shRNA (sc-29382-SH) was used to down-regulate TIMP-1 expression in human endothelial cells, demonstrating that reduced TIMP-1 levels led to decreased secretion of sVEGFR-1, thereby elucidating TIMP-1's regulatory role in ovarian angiogenesis.
Showing 1-1 of 1 papers.
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