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TIMP3 Human shRNA Plasmid Kit (Locus ID 7078)

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SKU
TR308813
TIMP3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 7078
Synonyms HSMRK222; K222; K222TA2; SFD
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components TIMP3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 7078). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_000362, NM_000362.1, NM_000362.2, NM_000362.3, NM_000362.4, BC014277, BC014277.2, BC013086, NM_000362.5
UniProt ID P35625
Summary This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Mesenchymal stem cells regulate blood-brain barrier integrity through TIMP3 release after traumatic brain injury
Menge, Zhao, Zhao et al
Sci Transl Med (2012) 4 (161), 161ra150 DOI: 10.1126/scitranslmed.3004660
Cited by 158
AI Summary: OriGene products contributed to this study by providing the TIMP3 shRNA (OriGene, TL506482) used to attenuate TIMP3 expression in mesenchymal stem cells, allowing the authors to demonstrate that TIMP3 is essential for MSC-mediated protection of blood-brain barrier integrity after traumatic brain injury.
FigureFigure
Showing 1-1 of 1 papers.
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