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TOPBP1 Human shRNA Plasmid Kit (Locus ID 11073)

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SKU
TR308695
TOPBP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 11073
Synonyms Dpb11; TOP2BP1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components TOPBP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 11073). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_007027, NM_007027.1, NM_007027.2, NM_007027.3, BC017552, BC032633, BC126209, BC151237, NM_001363889, NM_007027.4
UniProt ID Q92547
Summary This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress
Kumar, Mazzanti, Mistrik et al
Cell (2014) 158 (3), 633-46 DOI: 10.1016/j.cell.2014.05.046
Cited by 249
AI Summary: OriGene Technologies contributed RAD17-specific shRNAs, which were used to investigate the role of RAD17 in ATR-mediated responses to mechanical stress at the nuclear envelope.
Snippet: Chk1 was obtained from Leica. EdU (click-IT), RPA70-, TopBP1-, and RAD17-small hairpin RNAs (shRNAs) were obtained from Invitrogen and Origene Technologies, respectively. ATR-specific inhibitor and ATR shRNA were from Dr. Oscar Capetillo (Centro Nacional de Oncologia [CNIO]) (Toledo et al., 2011)
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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