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UHRF1 Human shRNA Plasmid Kit (Locus ID 29128)

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SKU
TR308492
UHRF1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 29128
Synonyms hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106; TDRD22
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components UHRF1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 29128). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001048201, NM_001290050, NM_001290051, NM_001290052, NM_013282, NM_013282.1, NM_013282.2, NM_013282.3, NM_013282.4, NM_001048201.1, NM_001048201.2, NM_001290050.1, NM_001290051.1, NM_001290052.1, BC113875, BC039136, BC046179, NM_001048201.3, NM_001290051.2
UniProt ID Q96T88
Summary This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. provided by RefSeq, Feb 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

UHRF1 and the DNA damage response
Mistry
Thesis (2011)
Snippet: Human HeLa cells (ATCC) were either transiently or stably transfected with one of four short hairpin RNA shRNA expression plasmids against UHRF1 (HuSH 29mer shRNA constructs against UHRF1, #TR308492, Origene, Rockville MD). T
Showing 1-1 of 1 papers.
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