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USP7 Human shRNA Plasmid Kit (Locus ID 7874)

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SKU
TR308454
USP7 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 7874
Synonyms HAFOUS; HAUSP; TEF1
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components USP7 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 7874). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001286457, NM_001286458, NM_003470, NM_001321858, NR_135826, NM_003470.1, NM_001286458.1, NM_001286457.1, BC166690, BM661563, NM_001286458.2, NM_003470.3
UniProt ID Q93009
Summary The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. provided by RefSeq, Mar 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation
Hu, Li, Zhang et al
Nucleic Acids Res. (2014)
Cited by 34
AI Summary: In this study, OriGene's shRNA targeting USP7 (TR308454) was used to investigate the role of USP7 in regulating H2A ubiquitination and cell proliferation.
Snippet: vector. The siRNA targeting USP7 was purchased from Santa Cruz (sc-41521). The shRNA targeting USP7 was from OriGene (TR308454). All the plasmids were verified by DNA sequencing. Cell culture and transfection. HCT116 ... Cite SaveSaving
Showing 1-1 of 1 papers.
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