ZFAND5 Human shRNA Plasmid Kit (Locus ID 7763)
Specifications
| Product Data | |
| Locus ID | 7763 |
|---|---|
| Synonyms | ZA20D2; ZFAND5A; ZNF216 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | ZFAND5 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 7763). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001102420, NM_001102421, NM_001278243, NM_001278244, NM_001278245, NM_006007, NM_006007.1, NM_006007.2, NM_006007.3, NM_001102420.1, NM_001102420.2, NM_001102421.1, NM_001102421.2, NM_001278243.1, NM_001278244.1, NM_001278245.1, BC073131, BC073131.1, BC011018, BC027707, NM_001102421.3, NM_001102420.3 |
| UniProt ID | O76080 |
| Summary | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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