NBPF1 Human shRNA Plasmid Kit (Locus ID 55672)
SKU
TR307077
NBPF1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 55672 |
|---|---|
| Synonyms | AB13; AB14; AB23; AD2; NBG; NBPF |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | NBPF1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 55672). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_017940, NM_017940.3, NM_017940.1, NM_017940.2, BC010124, BC013805, BC034418, BC066930, BC093404, BC094705, BC110431, BC169316, BC169317, BC169318 |
| UniProt ID | Q3BBV0 |
| Summary | This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. provided by RefSeq, Apr 2013 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest
Andries, Vandepoele, Staes et al
BMC Cancer (2015) 15 (1), 391 DOI: 10.1186/s12885-015-1408-5
Andries, Vandepoele, Staes et al
BMC Cancer (2015) 15 (1), 391 DOI: 10.1186/s12885-015-1408-5
Cited by 47
AI Summary: OriGene’s HuSH retroviral silencing vectors (shRNAs 9 to 16) were used in this study to specifically knock down NBPF1 expression, enabling the authors to investigate the gene’s role as a tumor suppressor in neuroblastoma and other cancer cell lines.
Snippet: Given are the target sequence, the predicted specificity (NBPF1-specific or broad NBPF specificity) and location in exons (for exon type, see ref. [4]) or 5’UTR. shRNAs 1 to 5 represent shRNAs with a stem length of 19 bps, whereas shRNAs 6 to 16 represent shRNAs with a stem length of 29 bps. …
Showing 1-1 of 1 papers.
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