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APH1A Human shRNA Plasmid Kit (Locus ID 51107)

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SKU
TR306646
APH1A - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 51107
Synonyms 6530402N02Rik; APH-1; APH-1A; CGI-78
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components APH1A - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 51107). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001077628, NM_001243771, NM_001243772, NM_016022, NR_045033, NR_045034, NR_045035, NM_016022.1, NM_016022.2, NM_016022.3, NM_001077628.1, NM_001077628.2, NM_001243771.1, NM_001243772.1, BC009501, BC009501.2, BC020590, BC020590.1, BC001230, BC008732, BC015568, BC017699, BC068606, NM_001077628.3
UniProt ID Q96BI3
Summary This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. provided by RefSeq, Aug 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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