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Caldesmon (CALD1) Human shRNA Plasmid Kit (Locus ID 800)

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SKU
TR305670
CALD1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 800
Synonyms CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CALD1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 800). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_004342, NM_018495, NM_033138, NM_033139, NM_033140, NM_033157, NM_004342.1, NM_004342.2, NM_004342.4, NM_004342.5, NM_004342.6, NM_033139.1, NM_033139.2, NM_033139.3, NM_033140.1, NM_033140.2, NM_033140.3, NM_033157.1, NM_033157.2, NM_033138.1, NM_033138.2, NM_033138.3, BC040354, BC040354.1, BC005006, BC014035, BC015839, BC061926, NM_004342.7, NM_033140.4, NM_033138.4
UniProt ID Q05682
Summary This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development
Pitts, Tan, Kulikowski et al
Clin Cancer Res (2010) 16 (12), 3193-204 DOI: 10.1158/1078-0432.CCR-09-3191
AI Summary: OriGene products contributed to this study by providing shRNA constructs (OriGene shRNA) used for gene knockdown experiments to validate candidate genes identified in the integrated genomic classifier for predicting response to the IGFIR inhibitor OSI-906 in colorectal cancer.
FigureFigure
Showing 1-1 of 1 papers.
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