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CDC42 Human shRNA Plasmid Kit (Locus ID 998)

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SKU
TR305497
CDC42 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 998
Synonyms CDC42Hs; G25K; TKS
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CDC42 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 998). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001039802, NM_001791, NM_044472, NM_001791.1, NM_001791.2, NM_001791.3, NM_044472.1, NM_044472.2, NM_001039802.1, BC018266, BC018266.1, BC002711, BC003682, BC018622, BM684474, NM_001791.4, NM_044472.3, NM_001039802.2
UniProt ID P60953
Summary The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. provided by RefSeq, Apr 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway
Wang, Sonn, Tekletsadik et al
J Cell Sci (2009) 122 (Pt 12), 2024-33 DOI: 10.1242/jcs.044644
Cited by 81
AI Summary: In this study, OriGene’s IQGAP1 plasmid (Cat# RC210774) and IQGAP1 shRNA (Cat# TL313960) were used to manipulate IQGAP1 expression, enabling the authors to investigate its role in cell proliferation and the CDC42-mTOR signaling pathway.
Showing 1-1 of 1 papers.
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