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ACKR3 Human shRNA Plasmid Kit (Locus ID 57007)

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SKU
TR305345
ACKR3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 57007
Synonyms chemokine (C-X-C motif) receptor 7; chemokine orphan receptor 1; CMKOR1; GPR159; G protein-coupled receptor; RDC1; RDC1, CMKOR1, GPR159
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components ACKR3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 57007). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001047841, NM_020311, NM_020311.1, NM_020311.2, NM_001047841.1, BC036661, BC036661.2, BC008459, BM925428, NM_020311.3
UniProt ID P25106
Summary This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

CXCR7 maintains osteosarcoma invasion after CXCR4 suppression in bone marrow microenvironment
Han, Wu, Wang et al
Tumour Biol. (2017) 39 (5), 1010428317701631 DOI: 10.1177/1010428317701631
Snippet: CXCR7 short hairpin RNA (shRNA) and scrambled sequence shRNA (control shRNA) constructs were cloned into pRS plasmid under the control of U6 promoter for stable expression (HuSh-29mer, OriGene, Rockville, MD)
The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation
Salazar, Muñoz, Kallifatidis et al
Mol. Cancer (2014) 13 (1), 198 DOI: 10.1186/1476-4598-13-198
Cited by 100
AI Summary: OriGene's HuSh-29mer shRNA constructs were used to stably knock down CXCR7 expression in breast cancer cells, enabling the authors to investigate the role of CXCR7 in cell proliferation and its interaction with EGFR.
Snippet: Briefly, CXCR7 shRNA and scrambled sequence shRNA (Control shRNA) constructs were cloned into a pRS plasmid under the control of a U6 promoter for stable expression (HuSh-29mer, Origene Technology Inc. Baltimore, MD). ... Cite SaveSaving
Showing 1-2 of 2 papers.
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