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CSN7b (COPS7B) Human shRNA Plasmid Kit (Locus ID 64708)

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SKU
TR305269
COPS7B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 64708
Synonyms CSN7B; SGN7b
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components COPS7B - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 64708). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001282949, NM_001282950, NM_001282951, NM_001282952, NM_001308381, NM_022730, NM_022730.1, NM_022730.2, NM_022730.3, NM_001282952.1, NM_001282952.2, NM_001282951.1, NM_001282951.2, NM_001282949.1, NM_001282949.2, NM_001282950.1, NM_001282950.2, BC010739, BC091493, NM_001369483, NM_001282949.3, NM_022730.4, NM_001282950.3
UniProt ID Q9H9Q2
Summary Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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