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EYA4 Human shRNA Plasmid Kit (Locus ID 2070)

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SKU
TR304714
EYA4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 2070
Synonyms CMD1J; DFNA10
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components EYA4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 2070). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001301012, NM_001301013, NM_004100, NM_172103, NM_172104, NM_172105, NM_172103.1, NM_172103.2, NM_172103.3, NM_004100.1, NM_004100.2, NM_004100.3, NM_004100.4, NM_172105.1, NM_172105.2, NM_172105.3, NM_001301012.1, NM_001301013.1, BC041063, BC014193, BC030588, NM_001370458, NM_001370459, NM_004100.5
UniProt ID O95677
Summary This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Jul 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Regulation of the innate immune response by threonine-phosphatase of Eyes absent
Okabe, Sano, Nagata
Nature (2009) 460 (7254), 520-4 DOI: 10.1038/nature08138
Cited by 167
AI Summary: OriGene products, specifically the EYA4 expression plasmid (OriGene, MC205779) and EYA4 shRNA (OriGene, TG313747), were used in this study to manipulate EYA4 levels in cells, enabling the authors to investigate the role of EYA4 in regulating the innate immune response to undigested DNA and viral infection.
Showing 1-1 of 1 papers.
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