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EZH2 Human shRNA Plasmid Kit (Locus ID 2146)

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SKU
TR304713
EZH2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 2146
Synonyms ENX-1; ENX1; EZH2b; KMT6; KMT6A; WVS; WVS2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components EZH2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 2146). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001203247, NM_001203248, NM_001203249, NM_004456, NM_152998, NM_004456.1, NM_004456.2, NM_004456.3, NM_004456.4, NM_152998.1, NM_152998.2, NM_001203249.1, NM_001203248.1, NM_001203247.1, BC010858, BC010858.2, BM974565, NM_001203249.2, NM_001203247.2, NM_004456.5, NM_001203248.2, NM_152998.3
UniProt ID Q15910
Summary This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. provided by RefSeq, Feb 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma
Liu, Liu, Liu et al
Nat Commun (2015) 6, 8494 DOI: 10.1038/ncomms9494
Cited by 137
AI Summary: In this study, OriGene products including EZH2 shRNA (OriGene, #TG311690) and CXCR4 shRNA (OriGene, #TG312699) were used to knock down EZH2 and CXCR4 expression, respectively, enabling the researchers to investigate the molecular mechanisms regulating CXCR4 in hepatocellular carcinoma.
Snippet: Cite SaveSaving
GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis
Ross, Mavoungou, Bresnick et al
Mol. Cell. Biol. (2012) 32 (18), 3624-38 DOI: 10.1128/MCB.00163-12
Cited by 5
AI Summary: OriGene's pGFP-V-RS shRNA vectors targeting EZH2 were used in this study to knock down EZH2 expression and investigate its role in the repression of Hes1 during erythroid cell differentiation.
Snippet: To knock down expression of Hes1, pLKO.1 vectors containing short hairpin RNA (shRNA) specific to Hes1 mRNA or a nonspecific scrambled shRNA ... The pGFP-V-RS vector (OriGene) transcribing the shRNA molecule 381 or 382 (both, directed against EZH2 RNA), MI-2-1 or MI
Showing 1-2 of 2 papers.
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