GSTM4 Human shRNA Plasmid Kit (Locus ID 2948)
SKU
TR304180
GSTM4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
2 Weeks*
Specifications
| Product Data | |
| Locus ID | 2948 |
|---|---|
| Synonyms | GSTM4-4; GTM4 |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | GSTM4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 2948). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_000850, NM_147148, NM_147149, NR_024538, NM_000850.1, NM_000850.2, NM_000850.3, NM_000850.4, NM_147148.1, NM_147148.2, BC015513, BC015513.1, BC108729, BM673461 |
| UniProt ID | Q03013 |
| Summary | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. provided by RefSeq, Jul 2008 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages
Dalli, Vlasakov, Riley et al
PNAS (2016) 113 (43), 12232-12237 DOI: 10.1073/pnas.1607003113
Dalli, Vlasakov, Riley et al
PNAS (2016) 113 (43), 12232-12237 DOI: 10.1073/pnas.1607003113
AI Summary: OriGene’s human recombinant LTC4S (HrLTC4S) enzyme was used to investigate the biosynthetic conversion of maresin epoxide intermediates to MCTR1 in human macrophages, helping to elucidate key steps in the tissue regeneration pathway.
Snippet: HrLTC4S (40 ng/20 μL;Origene) and hrGSTM4 (61 ng/20 μL;Creative Biomart) were suspended in 25 mM Tris·HCl containing 5 mM reduced glutathione and 0.05% Triton X-100 (pH 7.8) and incubated with 13S, 14S-eMaR or LTA4 (0.3, 1, 3, 10, 30, and 100 μM) at room temperature for 2 min. The incubations were quenched using 2 volumes of MeOH and were profiled using lipid mediator metabololipidomics
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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