HSD11B1 Human shRNA Plasmid Kit (Locus ID 3290)

SKU TR304036

HSD11B1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 3290
• Synonyms: 11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: HSD11B1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3290). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001206741, NM_005525, NM_181755, NM_005525.1, NM_005525.2, NM_005525.3, NM_181755.1, NM_181755.2, NM_001206741.1, BC012593, BC012593.1, BM994393, NM_005525.4
• UniProt ID: P28845
• Summary: The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient