HTRA3 Human shRNA Plasmid Kit (Locus ID 94031)
Specifications
| Product Data | |
| Locus ID | 94031 |
|---|---|
| Synonyms | Prsp; Tasp |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | HTRA3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 94031). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001297559, NM_053044, NM_053044.1, NM_053044.2, NM_053044.3, NM_053044.4, NM_001297559.1, BC035717, BC035717.1, BC034390, NM_001297559.2, NM_053044.5 |
| UniProt ID | P83110 |
| Summary | Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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