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IL27 Human shRNA Plasmid Kit (Locus ID 246778)

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SKU
TR303941
IL27 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 246778
Synonyms IL-27; IL-27A; IL27A; IL27p28; IL30; p28
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components IL27 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 246778). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_145659, NM_145659.1, NM_145659.2, NM_145659.3, BC062422, BC062422.1
UniProt ID Q8NEV9
Summary The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Interleukin-30 feeds breast cancer stem cells via CXCL10 and IL23 autocrine loops and shapes immune contexture and host outcome
Sorrentino, Ciummo, D'Antonio et al
J Immunother Cancer (2021) 9 (10) DOI: 10.1136/jitc-2021-002966
Cited by 29
AI Summary: OriGene’s IL27 Human Tagged ORF Clone (#RC209337L1) was used in this study to transiently overexpress human IL30 in breast cancer stem cells, enabling the authors to investigate IL30’s role in promoting cancer stem cell proliferation and tumor progression.
Snippet: Expression of IL30 was confirmed by real-time RT-PCR, Western blotting (WB) and ELISA. For transient overexpression of human IL30 in BCSC-608, we used the IL27 Human Tagged ORF Clone (#RC209337L1;Origene, Rockville, MD, USA), which was transfected in BCSC-608 cells using Lipofectamine 3000 Reagent (#L3000001;Thermo Fisher Scientific, Waltham, MA, USA). Overexpression of IL30 was confirmed by
FigureFigureFigure
Showing 1-1 of 1 papers.
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