INPP5E Human shRNA Plasmid Kit (Locus ID 56623)
Specifications
| Product Data | |
| Locus ID | 56623 |
|---|---|
| Synonyms | CORS1; CPD4; JBTS1; MORMS; pharbin; PPI5PIV |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | INPP5E - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 56623). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001318502, NM_019892, NM_019892.1, NM_019892.2, NM_019892.3, NM_019892.4, NM_019892.5, BC028032, BC028032.1, BC110356, NM_019892.6 |
| UniProt ID | Q9NRR6 |
| Summary | The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Jan 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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