MCL1 Human shRNA Plasmid Kit (Locus ID 4170)
SKU
TR303313
MCL1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 4170 |
|---|---|
| Synonyms | bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | MCL1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 4170). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001197320, NM_021960, NM_182763, NM_021960.1, NM_021960.2, NM_021960.3, NM_021960.4, NM_182763.1, NM_182763.2, NM_001197320.1, BC017197, BC017197.2, BC071897, BC107735, NM_021960.5 |
| UniProt ID | Q07820 |
| Summary | This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. provided by RefSeq, Oct 2010 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Dinaciclib, a CDK inhibitor promotes proteasomal degradation of Mcl-1 and enhances ABT-737 mediated cell death in malignant human glioma cell lines
Jane, Premkumar, Cavaleri et al
J. Pharmacol. Exp. Ther. (2015)
Jane, Premkumar, Cavaleri et al
J. Pharmacol. Exp. Ther. (2015)
Cited by 45
AI Summary: OriGene products contributed to this paper by providing 29mer-pRS-shRNA constructs for gene silencing and the MCL-1 expression plasmid (catalog number RC200521) for overexpression studies, enabling the researchers to investigate the role of Mcl-1 in glioma cell response to dinaciclib and ABT-737.
Snippet: described above. Transient transfection Optimal 29mer-pRS-shRNA constructs were obtained from OriGene (Rockville, MD). Sequences ... For overexpression studies, cells were transfected with 2.0 µg of MCL-1 expression plasmid (catalog number RC200521, OriGene ... Cite SaveSaving
Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin
Jani, DeVecchio, Mazumdar et al
J Biol Chem (2010) 285 (25), 19162-72 DOI: 10.1074/jbc.M109.091645
Jani, DeVecchio, Mazumdar et al
J Biol Chem (2010) 285 (25), 19162-72 DOI: 10.1074/jbc.M109.091645
AI Summary: OriGene's shRNA constructs targeting c-FLIP and Mcl-1 were used to knock down these genes in colon carcinoma cell lines, demonstrating that reduced expression of these NF-kappaB-regulated survival factors significantly increased sensitivity to TRAIL and oxaliplatin-induced cell death.
Showing 1-2 of 2 papers.
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