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NEIL2 Human shRNA Plasmid Kit (Locus ID 252969)

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SKU
TR302986
NEIL2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 252969
Synonyms NEH2; NEI2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components NEIL2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 252969). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001135746, NM_001135747, NM_001135748, NM_145043, NM_001349439, NM_001349440, NM_001349441, NM_001349442, NR_146180, NR_146181, NR_146182, NM_145043.1, NM_145043.2, NM_145043.3, NM_001135748.1, NM_001135748.2, NM_001135746.1, NM_001135746.2, NM_001135747.1, NM_001135747.2, BC013952, BC013952.2, BC013964, BC045822, NM_001135747.3, NM_001135748.3, NM_001135746.3
UniProt ID Q969S2
Summary This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. provided by RefSeq, Mar 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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