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RBM25 Human shRNA Plasmid Kit (Locus ID 58517)

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SKU
TR302072
RBM25 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 58517
Synonyms fSAP94; NET52; RED120; RNPC7; S164; Snu71
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components RBM25 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 58517). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_021239, NM_021239.1, NM_021239.2, BC033664, BC062440, BC083496, BC111066, BC113389, BC113391, BC136775, BC136776, BC144407
UniProt ID P49756
Summary RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection
Zhou, Ou, Cho et al
Mol Cell Biol (2008) 28 (19), 5924-36 DOI: 10.1128/MCB.00560-08
AI Summary: In this study, OriGene’s RBM25 expression plasmid (Cat# RC203307) and RBM25 shRNA (Cat# TL313885) were used to modulate RBM25 levels in cells, enabling the authors to investigate RBM25’s role in regulating Bcl-x pre-mRNA alternative splicing and apoptosis.
FigureFigureFigure
Showing 1-1 of 1 papers.
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