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SIRT2 Human shRNA Plasmid Kit (Locus ID 22933)

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SKU
TR301692
SIRT2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 22933
Synonyms SIR2; SIR2L; SIR2L2
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components SIRT2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 22933). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001193286, NM_012237, NM_030593, NR_034146, NM_030593.1, NM_030593.2, NM_012237.1, NM_012237.2, NM_012237.3, NM_001193286.1, BC003547, BC003547.1, BC003012, NM_012237.4, NM_030593.3
UniProt ID Q8IXJ6
Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. provided by RefSeq, Jul 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism
Karwaciak, Sałkowska, Karaś et al
Int J Mol Sci (2021) 22 (9) DOI: 10.3390/ijms22095034
Cited by 15
AI Summary: OriGene products, specifically the SIRT2 shRNA (OriGene, TG311279) and SIRT2 overexpression plasmid (OriGene, RC222667), were used to manipulate SIRT2 expression in melanoma cells, enabling the authors to demonstrate that SIRT2 inhibition sensitizes melanoma cells to cisplatin by affecting EGFR pathway signaling.
FigureFigureFigure
SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib
Karwaciak, Sałkowska, Karaś et al
Cancers (Basel) (2019) 11 (5) DOI: 10.3390/cancers11050673
AI Summary: OriGene products—specifically the SIRT2 shRNA plasmid (T301692D) and the scrambled negative control shRNA plasmid (TR30012)—were used to generate stable SIRT2-silenced melanoma cell lines, enabling the study of SIRT2's role in resistance to dasatinib.
Snippet: sh stable SIRT2-silenced cell lines, MDA-MB-435S and WM853 cells were transfected with short hairpin RNA (shRNA) plasmids: scrambled negative control noneffective shRNA (TR30012) or SIRT2 (T301692D) (Origene Tech. …sh stable SIRT2-silenced cell lines, MDA-MB-435S and WM853 cells were transfected with short hairpin RNA (shRNA) plasmids: scrambled negative control noneffective shRNA (TR30012) or SIRT2 (T301692D) (Origene Tech. …The cells were then cultured by replacing t;;To establish stable SIRT2-silenced cell lines, MDA-MB-435S and WM853 cells were transfected with short hairpin RNA (shRNA) plasmids: scrambled negative control noneffective shRNA (TR30012) or SIRT2 (T301692D) (Origene Tech. …
Showing 1-2 of 2 papers.
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