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SPHK1 Human shRNA Plasmid Kit (Locus ID 8877)

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SKU
TR301413
SPHK1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 8877
Synonyms SPHK
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components SPHK1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 8877). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001142601, NM_001142602, NM_021972, NM_182965, NM_001355139, NM_021972.1, NM_021972.2, NM_021972.3, NM_182965.1, NM_182965.2, NM_001142602.1, NM_001142601.1, BC009419, BC009419.1, BC030553, BC008040, BC004112, BC014439, NM_021972.4
UniProt ID Q9NYA1
Summary The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Sep 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer
Liang, Xie, Cui et al
J. Cancer Res. Clin. Oncol. (2016)
AI Summary: OriGene contributed to this study by providing SphK1-shRNA clones (catalog no: TR301413), which were used to knock down SphK1 expression and investigate its role in papillary thyroid cancer.
Snippet: The SphK1 construct was generated by subcloning polymerase chain reaction (PCR)-amplified full-length human SphK1 cDNA into a pMSCV plasmid. The SphK1-shRNA clones (catalog no: TR301413) were purchased from OriGene (Rockville, MD, USA). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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