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TLR9 Human shRNA Plasmid Kit (Locus ID 54106)

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SKU
TR301076
TLR9 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 54106
Synonyms CD289
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components TLR9 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 54106). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_017442, NM_138688, NM_017442.1, NM_017442.2, NM_017442.3, NM_138688.1, BC032713, BC032713.1
UniProt ID Q9NR96
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. provided by RefSeq, Aug 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis
Pal, Daniels, Oskman et al
MBio (2016) 7 (3) DOI: 10.1128/mBio.00617-16
AI Summary: OriGene products contributed to this study by providing shRNAs targeting Myd88 (TG311320), NFκB (TR318700), caspase-1 (TG305640), TLR9 (TR301076), TLR5 (TR308792), and TLR2 (TR320553), which were used to investigate the molecular pathways involved in HRPII-induced disruption of brain endothelial barriers.
Snippet: Cells were then incubated for 36 h. HRPII was then added, and TEER measurements were recorded over 24 h. shRNAs for each gene were purchased from Origene as follows: for the Myd88 gene, TG311320;for the NFκB gene, TR318700;for the caspase-1 gene, TG305640;for the TLR9 gene, TR301076;for the TLR5 gene, TR308792;and for the TLR2 gene, TR320553
The Role of Histidine Rich Protein II in Cerebral Malaria
Pal
Thesis (2017)
Snippet: …shRNAs for each gene were purchased from Origene : Myd88 (TG311320), NFкB (TR318700), Caspase-1 (TG305640), TLR9 (TR301076), TLR5 (TR308792), TLR2 (TR320553);of the four shRNAs received from the vendor, 2-3 were used based on silencing efficiency in pilot studies
The Role of Histidine Rich Protein II in Cerebral Malaria Pathogenesis
Pal
Thesis (2017)
Snippet: shRNAs for each gene were purchased from Origene : Myd88 (TG311320), NFB (TR318700), Caspase-1 (TG305640), TLR9 (TR301076), TLR5 (TR308792), TLR2 (TR320553);of the four shRNAs received from the vendor, 2-3 were used based on silencing efficiency ... Cite SaveSaving
Showing 1-3 of 3 papers.
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