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TRPC4 Human shRNA Plasmid Kit (Locus ID 7223)

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SKU
TR300814
TRPC4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
  $883.00
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Other products for "TRPC4 or NM_001135955"

Specifications
Specifications
Product Data
Locus ID 7223
Synonyms HTRP-4; HTRP4; TRP4
Vector pRS
E. coli Selection Ampicillin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components TRPC4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 7223). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq NM_001135955, NM_001135956, NM_001135957, NM_001135958, NM_003306, NM_016179, NM_001354799, NM_001354806, NM_016179.1, NM_016179.2, NM_003306.1, NM_001135955.1, NM_001135956.1, NM_001135957.1, NM_001135958.1, BC104725, BC105306, BC105641, BC105917, NM_001135956.3, NM_016179.4, NM_001135958.3, NM_001135957.3, NM_001135955.3, NM_003306.3
UniProt ID Q9UBN4
Summary This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. provided by RefSeq, Aug 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration
Potier, Gonzalez, Motiani et al
FASEB J (2009) 23 (8), 2425-37 DOI: 10.1096/fj.09-131128
Cited by 264
AI Summary: In this study, OriGene’s STIM1 and Orai1 siRNA/shRNA products were used to knock down gene expression, demonstrating that these proteins are essential for store-operated calcium entry and related vascular smooth muscle cell functions.
FigureFigureFigure
Showing 1-1 of 1 papers.
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