WISP1 Human shRNA Plasmid Kit (Locus ID 8840)
SKU
TR300454
WISP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 8840 |
|---|---|
| Synonyms | WISP1; WISP1-OT1; WISP1-UT1; WISP1c; WISP1i; WISP1tc |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | WISP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 8840). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_001204869, NM_001204870, NM_003882, NM_080838, NR_037944, NM_003882.1, NM_003882.2, NM_003882.3, NM_080838.1, NM_080838.2, NM_001204870.1, BC074840, BC074840.2, BC074841, NM_001204869.2, NM_001204870.2, NM_003882.4, NM_080838.3 |
| UniProt ID | O95388 |
| Summary | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. provided by RefSeq, Mar 2011 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death
Venkatachalam, Venkatesan, Valente et al
J Biol Chem (2009) 284 (21), 14414-27 DOI: 10.1074/jbc.M809757200
Venkatachalam, Venkatesan, Valente et al
J Biol Chem (2009) 284 (21), 14414-27 DOI: 10.1074/jbc.M809757200
AI Summary: In this study, OriGene’s WISP1 siRNA (SR304017) and WISP1 expression plasmid (RC209684) were used to knock down and overexpress WISP1, respectively, enabling the authors to demonstrate WISP1’s role in mediating TNF-alpha-stimulated cardiac fibroblast proliferation and protecting cardiomyocytes from TNF-alpha-induced death.
Showing 1-1 of 1 papers.
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