OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

CFTR (NM_000492) Human Recombinant Protein

Be the first to review this product
SKU
TP762269
Purified recombinant protein of Human cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR), Pro1181-End, with N-terminal His tag, expressed in E.coli, 50ug
Size:
50 ug
  $260.00
In Stock*
Bulk/Customize

Frequently Bought Together (1)

TA890106 Rabbit Polyclonal anti-CFTR Antibody
100 ul
$410.00

Other products for "CFTR or NM_000492"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding the region(Pro1181-End) of CFTR
Tag N-His
Predicted MW 33.9 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 8 M urea
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_000483
Locus ID 1080
UniProt ID P13569
Cytogenetics 7q31.2
RefSeq Size 6132
RefSeq ORF 4440
Synonyms ABC35; ABCC7; CF; CFTR/MRP; dJ760C5.1; MRP7; TNR-CFTR
Summary This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. provided by RefSeq, Aug 2017
Protein Categories Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, Transmembrane
Protein Pathways ABC transporters, Vibrio cholerae infection
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Toxoplasma gondii infection triggers ongoing inflammation mediated by increased intracellular Cl− concentration in airway epithelium
Qiu, Chen, Hou et al
Journal of Infection (2022) 86 (1), 47-59 DOI: 10.1016/j.jinf.2022.10.037
Cited by 7
AI Summary: In this study, OriGene’s purified recombinant human CFTR protein (TP762269) was used to investigate how Toxoplasma gondii-secreted factors degrade CFTR in airway epithelial cells, contributing to the understanding of inflammation mechanisms in pulmonary toxoplasmosis.
Snippet: …Purified recombinant human CFTR protein, purchased from OriGene Technologies (TP762269, Rockville, MD, USA), was incubated for 2 h with the cell-free supernatants of T. gondii tachyzoites cultured in BEAS-2B cells
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products