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MAP3K8 (NM_005204) Human Recombinant Protein

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SKU
TP762217
Purified recombinant protein of Human mitogen-activated protein kinase kinase kinase 8 (MAP3K8), Met277-Pro461, with N-terminal His tag, expressed in E.coli, 50ug
Size:
50 ug
  $260.00
In Stock*
Bulk/Customize

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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding the region(Met277-Pro461) of MAP3K8
Tag N-His
Predicted MW 21.0 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 8 M urea
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_005195
Locus ID 1326
UniProt ID P41279
Cytogenetics 10p11.23
RefSeq Size 3013
RefSeq ORF 1401
Synonyms AURA2; c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2
Summary This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. provided by RefSeq, Sep 2011
Protein Categories Enzyme: Kinases, Intracellular Proteins
Protein Families Druggable Genome, Protein Kinase
Protein Pathways MAPK signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway
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Other "MAP3K8" proteins (2)
SKU Description Size Price
LC401593 Lyophilized MAP3K8 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY401593 Transient overexpression lysate of mitogen-activated protein kinase kinase kinase 8 (MAP3K8) (as WB positive control) 100 ug
$436.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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