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Androgen Receptor (AR) (NM_001011645) Human Recombinant Protein

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SKU
TP761906
Purified recombinant protein of Human androgen receptor (AR), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length AR
Tag N-GST and C-His
Predicted MW 72.5 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001011645
Locus ID 367
UniProt ID P10275
Cytogenetics Xq12
RefSeq Size 1765
RefSeq ORF 1164
Synonyms AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM
Summary The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Jan 2017
Protein Categories Growth Factors, Intracellular Proteins, Nervous system: Neurodegenerative diseases, Transciption Factors
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways Oocyte meiosis, Pathways in cancer, Prostate cancer
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Other "Androgen Receptor" proteins (4)
SKU Description Size Price
LC400012 Lyophilized AR HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC423281 Lyophilized AR HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400012 Transient overexpression lysate of androgen receptor (AR), transcript variant 1 (as WB positive control) 100 ug
$665.00
LY423281 Transient overexpression lysate of androgen receptor (AR), transcript variant 2 (as WB positive control) 100 ug
$436.00

file-alt Citations

Christmas disease in a Hovawart family resembling human hemophilia B Leyden is caused by a single nucleotide deletion in a highly conserved transcription factor binding site of the F9 gene promoter
Brenig, Steingräber, Shan et al
bioRxiv (2018)
Snippet: underlined). The position of the 234 deleted C-nucleotide is indicated in bold and italics. Recombinant human HNF4α and human 235 AR over-expression lysate were purchased from Origene Technologies Inc. (Rockville, USA). 236 View as HTML
Showing 1-1 of 1 papers.
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