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CCN4 (NM_080838) Human Recombinant Protein

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SKU
TP761856
Purified recombinant protein of Human WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Size:
50 ug
  $270.00
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length WISP1
Tag N-GST and C-His
Predicted MW 56.3 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 8 M urea
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_543028
Locus ID 8840
UniProt ID O95388
Cytogenetics 8q24.22
RefSeq Size 1035
RefSeq ORF 840
Synonyms WISP1; WISP1-OT1; WISP1-UT1; WISP1c; WISP1i; WISP1tc
Summary This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. provided by RefSeq, Mar 2011
Protein Categories Cytokines, Growth Factors, Secreated Proteins
Protein Families Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - Wnt Signaling pathway
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Other "CCN4" proteins (6)
SKU Description Size Price
PH310402 WISP1 MS Standard C13 and N15-labeled recombinant protein (NP_003873) 10 ug
$3,360.00
LC403320 Lyophilized WISP1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC418374 Lyophilized WISP1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY403320 Transient overexpression lysate of WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 2 (as WB positive control) 100 ug
$436.00
LY418374 Transient overexpression lysate of WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 1 (as WB positive control) 100 ug
$436.00
TP310402 Recombinant protein of human WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 1, 20 µg 20 ug
$867.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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