MSL2L1 (MSL2) (NM_018133) Human Recombinant Protein

SKU TP760587

Purified recombinant protein of Human male-specific lethal 2 homolog (Drosophila) (MSL2), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding human full-length MSL2
• Tag: N-His
• Predicted MW: 62.4 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_060603
• Locus ID: 55167
• UniProt ID: Q9HCI7
• Cytogenetics: 3q22.3
• RefSeq Size: 4696
• RefSeq ORF: 1731
• Synonyms: MSL-2; MSL2L1; RNF184
• Summary: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.[UniProtKB/Swiss-Prot Function]
• Protein Families: Druggable Genome