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Nrf2 (NFE2L2) (NM_006164) Human Recombinant Protein

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SKU
TP760529
Purified recombinant protein of Human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length NFE2L2
Tag N-His
Predicted MW 67.6 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 8 M urea
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_006155
Locus ID 4780
UniProt ID Q16236
Cytogenetics 2q31.2
RefSeq Size 2859
RefSeq ORF 1815
Synonyms HEBP1; IMDDHH; Nrf-2; NRF2
Summary This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. provided by RefSeq, Sep 2015
Protein Categories Cancer: Gastrointestinal, Intracellular Proteins, Transciption Factors
Protein Families Transcription Factors
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Other "Nrf2" proteins (2)
SKU Description Size Price
PH304140 NFE2L2 MS Standard C13 and N15-labeled recombinant protein (NP_006155) 10 ug
$3,360.00
TP304140 Recombinant protein of human nuclear factor (erythroid-derived 2)-like 2 (NFE2L2), transcript variant 1, 20 µg 20 ug
$867.00

file-alt Citations

1,8-Cineole alleviates Nrf2-mediated redox imbalance and mitochondrial dysfunction in diabetes mellitus by targeting Sirt1
Yang, Chen, Linghu et al
Phytomedicine (2024) 135, 156099 DOI: 10.1016/j.phymed.2024.156099
Cited by 16
AI Summary: OriGene’s recombinant human Nrf2 protein (TP760529) was used to assess the binding interactions between Nrf2 and 1,8-Cineole, contributing to the study’s analysis of molecular mechanisms underlying the protective effects of 1,8-Cineole in diabetes.
Snippet: The binding capacity of Sirt1 to 1,8-Cineole or recombinant human Nrf2 Protein (TP760529, full length;OriGene, Beijing, China) was assessed with Biacore evaluation 3.1 analysis software (GE Healthcare). The affinity results of various concentrations of 1,8-Cineole and Nrf2 were subjected to global fitting to determine equilibrium dissociation constants (KDs)
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
Sanghvi, Leibold, Mina et al
Cell (2019) 178 (4), 807-819.e21 DOI: 10.1016/j.cell.2019.07.031
AI Summary: OriGene’s recombinant human NRF2 protein (Cat#TP760529) was used in this study to investigate the dependence of NRF2 activity on FN3K-mediated de-glycation, enabling key experiments on NRF2 glycation, stability, and function.
Snippet: Recombinant human NRF2 Origene Cat#TP760529 Erlotinib Selleck Chemicals Cat#S1023 MG-132 Sigma-Aldrich Cat#M7449 Trametinib Selleck Chemicals Cat#S2673 NAC Sigma-Aldrich Cat#A7250 BSO Sigma-Aldrich Cat#B2640 Ganciclovir Sigma-Aldrich Cat#G2536 Critical Commercial Assays
Figure
Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway
He, Owen, Jelinsky et al
Sci Rep (2015) 5, 14368 DOI: 10.1038/srep14368
Cited by 71
AI Summary: OriGene products, including DDK (FLAG)-tagged SETD7 human ORF clone, NFE2L2 human cDNA clone, pCMV6-DDK tagged empty vectors, and the Anti-DDK Magnetic Immunoprecipitation Kit, were used to express and purify proteins for studying the interaction between SETD7 and NFE2L2 in the regulation of ROS signaling.
Snippet: Plasmids and transfection. DDK (FLAG)-tagged SETD7 human ORF clone, NFE2L2 human cDNA clone and pCMV6-DDK tagged empty vectors were obtained from Origene. ... Protein pull-down was performed with Anti-DDK Magnetic Immunoprecipitation Kit (Origene ... Cite SaveSaving
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Showing 1-3 of 3 papers.
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