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PPP4C (NM_002720) Human Recombinant Protein

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SKU
TP760519
Purified recombinant protein of Human protein phosphatase 4, catalytic subunit (PPP4C), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length PPP4C
Tag N-His
Predicted MW 34.9 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002711
Locus ID 5531
UniProt ID P60510
Cytogenetics 16p11.2
RefSeq Size 1429
RefSeq ORF 921
Synonyms PP-X; PP4; PP4C; PPH3; PPP4; PPX
Summary Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.UniProtKB/Swiss-Prot Function
Protein Categories Intracellular Proteins
Protein Families Druggable Genome, Phosphatase
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Documents
Resources

file-alt Citations

Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4
Yang, Chang, Yeh
Proc Natl Acad Sci U S A (2021) 118 (47) DOI: 10.1073/pnas.2107044118
Cited by 14
AI Summary: OriGene’s recombinant human PP4 protein (ORITP760519) was used in vitro to study the dephosphorylation of phosphorylated sNASP, helping to elucidate PP4's role as a negative regulator in TLR4 signaling.
Snippet: prepared by immunoprecipitation using GFP-Trap_M (gtm-20, Chromotek) was phosphorylated by casein kinase II (P6010, New England Biolabs) in vitro for 60 min at 30 C and followed by incubation with recombinant human PP4 protein (ORITP760519, Origene)
Showing 1-1 of 1 papers.
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