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PDGF beta (PDGFB) (NM_002608) Human Recombinant Protein

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SKU
TP760506
Purified recombinant protein of Human platelet-derived growth factor beta polypeptide (PDGFB), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length PDGFB
Tag N-His
Predicted MW 24.9 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002599
Locus ID 5155
UniProt ID P01127
Cytogenetics 22q13.1
RefSeq Size 3393
RefSeq ORF 723
Synonyms c-sis; IBGC5; PDGF-2; PDGF2; SIS; SSV
Summary This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. provided by RefSeq, Oct 2015
Protein Categories Cancer: Brain and CNS, Cancer: Lung, Growth Factors, Intracellular Proteins, Nervous system: Neurodegenerative diseases, Secreated Proteins
Protein Families Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma
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Other "PDGF beta" proteins (5)
SKU Description Size Price
LC400920 Lyophilized PDGFB HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC409779 Lyophilized PDGFB HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400920 Transient overexpression lysate of platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) (PDGFB), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY409779 Transient overexpression lysate of platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) (PDGFB), transcript variant 2 (as WB positive control) 100 ug
$436.00
TP720176 Recombinant protein of human platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) (PDGFB), transcript variant 1 10 ug
$340.00

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