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IL4 (NM_000589) Human Recombinant Protein

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SKU
TP723731
Purified recombinant protein of Human interleukin 4 (IL4), transcript variant 1
Size:
10 ug
  $345.00
5 Days*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
Human IL-4, the region of His25-Ser153, from gene Accession# NM_000589
Tag Tag Free
Predicted MW 14.9 kDa
Concentration lot specific
Purity Purity is >95%, as determined by Coomassie stained SDS-PAGE.
Buffer PBS, pH 7.2 (0.22 µm filtered).
Bioactivity The ED50 is 0.2 - 0.6 ng/ml, corresponding to a specific activity of 1.65 - 5 x 10^6 units/mg, determined by the dose dependent stimulation of TF-1 cell proliferation.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_000580
Locus ID 3565
UniProt ID P05112
Cytogenetics 5q31.1
RefSeq Size 921
RefSeq ORF 459
Synonyms BCGF-1; BCGF1; BSF-1; BSF1; IL-4
Summary The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. provided by RefSeq, Aug 2020
Protein Categories Allergies and autoimmune diseases, Cytokines, Growth Factors, Secreated Proteins
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Jak-STAT signaling pathway, T cell receptor signaling pathway
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Other "IL4" proteins (7)
SKU Description Size Price
PH309972 IL4 MS Standard C13 and N15-labeled recombinant protein (NP_000580) 10 ug
$3,360.00
LC406716 Lyophilized IL4 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
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LY406716 Transient overexpression lysate of interleukin 4 (IL4), transcript variant 2 (as WB positive control) 100 ug
$436.00
TP309972 Purified recombinant protein of Homo sapiens interleukin 4 (IL4), transcript variant 1, 20 µg 20 ug
$867.00
TP720041 Recombinant protein of human interleukin 4 (IL4), transcript variant 1 10 ug
$290.00
TP750015 Recombinant protein of human Interleukin 4 (IL-4) produced in E. coli. 50 ug
$540.00
TP760207 Recombinant protein of human interleukin 4 (IL4), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug 50 ug
$270.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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