PTPRN (NM_002846) Human Recombinant Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | N-His |
| Predicted MW | 35.6 kDa |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
| Storage | Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
| Stability | Stable for at least 3 months from date of receipt under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002837 |
| Locus ID | 5798 |
| UniProt ID | Q16849 |
| Cytogenetics | 2q35 |
| RefSeq Size | 3649 |
| RefSeq ORF | 2937 |
| Synonyms | IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N |
| Summary | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.provided by RefSeq, Dec 2010 |
| Protein Categories | Growth Factors, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Type I diabetes mellitus |
Reviews
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