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SLP76 (LCP2) (NM_005565) Human Recombinant Protein

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SKU
TP721201
Purified recombinant protein of Human lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2)
Size:
10 ug 500 ug 50 ug 1 mg
  $340.00
5 Days*
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Frequently Bought Together (1)

TA814187 LCP2 mouse monoclonal antibody, clone OTI7E8 100 ul
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
Met1-Pro533
Tag N-T7&C-His
Predicted MW 62.6 kDa
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 200mM NaCl, 20% Glycerol, pH 8.5.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_005556
Locus ID 3937
UniProt ID Q13094
Cytogenetics 5q35.1
RefSeq Size 2472
RefSeq ORF 1599
Synonyms IMD81; SLP-76; SLP76
Summary This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. provided by RefSeq, Nov 2016
Protein Categories Growth Factors, Immune system diseases, Intracellular Proteins
Protein Pathways Fc epsilon RI signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway
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Other "SLP76" proteins (4)
SKU Description Size Price
PH304404 LCP2 MS Standard C13 and N15-labeled recombinant protein (NP_005556) 10 ug
$3,360.00
LC417227 Lyophilized LCP2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY417227 Transient overexpression lysate of lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2) (as WB positive control) 100 ug
$436.00
TP304404 Recombinant protein of human lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2), 20 µg 20 ug
$867.00

file-alt Citations

T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells
Tewari, Shayahati, Fan et al
J Biol Chem (2021) 296, 100311 DOI: 10.1016/j.jbc.2021.100311
Cited by 32
AI Summary: In this study, OriGene products—including the pCMV6-ZAP70 expression plasmid and ZAP70-specific antibodies—were used to express and detect ZAP-70, enabling the authors to investigate how S-acylation regulates its role in T cell activation.
FigureFigureFigure
T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells
Tewari, Shayahati, Fan et al
bioRxiv (2020)
Cited by 3
Snippet: NP-40 and 10 mM MgCl2) and resuspended in 100 µl of the kinase buffer. 100 µM ATP, 1 mM DTT and 0.25 µg recombinant SLP-76 (OriGene, Cat. TP721201) were then added to the sample and incubated at 30 °C for 60 min
Showing 1-2 of 2 papers.
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