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HMGB2 (NM_002129) Human Recombinant Protein

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SKU
TP720732L
Purified recombinant protein of Human high mobility group box 2 (HMGB2), transcript variant 1
Size:
500 ug 10 ug 50 ug 1 mg
  $2,465.00
9 Weeks*
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Gly2-Glu209
Tag C-His
Predicted MW 25.07 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl, 100mM NaCl, pH 8.0.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reconstitution Method Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Shipping Ambient
Reference Data
RefSeq NP_002120
Locus ID 3148
UniProt ID P26583
Cytogenetics 4q34.1
RefSeq Size 1527
RefSeq ORF 627
Synonyms HMG2
Summary This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. provided by RefSeq, Jul 2008
Protein Categories Intracellular Proteins, Secreated Proteins
Protein Families Druggable Genome, Transcription Factors
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Documents
Resources

file-alt Citations

A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage
Yamamoto, Scavenius, Meschis et al
Matrix Biol (2022) 112, 190-218 DOI: 10.1016/j.matbio.2022.08.007
Cited by 23
AI Summary: OriGene’s recombinant human HMGB2 (C-terminal His tag, TP720732) was used in direct binding assays to confirm HMGB2 as a novel LRP1 ligand in human chondrocytes in this study.
Snippet: … It plays tissue-specific roles by mediating Save;C-terminal His tag, 14890-H08H) from Sino Biological (Beijing, China);recombinant human HMGB2 (C-terminal His tag, TP720732) from ORIGENE (Rockville, MD);anti-rabbit alkaline phosphatase-linked antibody, anti-mouse alkaline phosphatase-linked antibody, anti-goat alkaline phosphatase-linked antibody and alkaline phosphatas
Showing 1-1 of 1 papers.
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